Progress in Artificial Economics

Artificial economics aims to provide a generative approach to understanding problems in economics and social sciences. It is based on the consistent use of agent-based models and computational techniques. It encompasses a rich variety of techniques that generalize numerical analysis, mathematical programming, and micro-simulations. The peer-reviewed contributions in this volume address applications of artificial economics to markets and trading, auctions, networks, management, industry sectors, macroeconomics, and demographics and culture

Thyroid-specific transcription factors control Hex promoter activity

The homeobox-containing gene Hex is expressed in several cell types, including thyroid follicular cells, in which it regulates the transcription of tissue-specific genes. In this study the regulation of Hex promoter activity was investigated. Using co-transfection experiments, we demonstrated that the transcriptional activity of the Hex gene promoter in rat thyroid FRTL-5 cells is ∼10-fold greater than that observed in HeLa and NIH 3T3 cell lines (which do not normally express the Hex gene). To identify the molecular mechanisms underlying these differences, we evaluated the effect of the thyroid-specific transcription factor TTF-1 on the Hex promoter activity. TTF-1 produced 3-4-fold increases in the Hex promoter activity. Gel-retardation assays and mutagenesis experiments revealed the presence of functionally relevant TTF-1 binding sites in the Hex promoter region. These in vitro data may also have functional relevance in vivo, since a positive correlation between TTF-1 and Hex mRNAs was demonstrated in human thyroid tissues by means of RT-PCR analysis. The TTF-1 effect, however, is not sufficient to explain the difference in Hex promoter activity between FRTL-5 and cells that do not express the Hex gene. For this reason, we tested whether Hex protein is able to activate the Hex promoter. Indeed, co-transfection experiments indicate that Hex protein is able to increase the activity of its own promoter in HeLa cells ∼4-fold. TTF-1 and Hex effects are additive: when transfected together in HeLa cells, the Hex promoter activity is increased 6-7-fold. Thus, the contemporary presence of both TTF-1 and Hex could be sufficient to explain the higher transcriptional activity of the Hex promoter in thyroid cells with respect to cell lines that do not express the Hex gene. These findings demonstrate the existence of direct cross-regulation between thyroid-specific transcription factors

Effect of the Austempering Process on the Microstructure and Mechanical Properties of 27MnCrB5-2 Steel

AbstractThe effect of austempering parameters on the microstructure and mechanical properties of 27MnCrB5-2 steel has been investigated by means of: dilatometric, microstructural and fractographic analyses; tensile and Charpy V-notch (CVN) impact tests at room temperature and a low temperature.Microstructural analyses showed that upper bainite developed at a higher austempering temperature, while a mixed bainitic-martensitic microstructure formed at lower temperatures, with a different amount of bainite and martensite and a different size of bainite sheaf depending on the temperature. Tensile tests highlighted superior yield and tensile strengths (≈30%) for the mixed microstructure, with respect to both fully bainitic and Q&T microstructures, with only a low reduction in elongation to failure (≈10%). Impact tests confirmed that mixed microstructures have higher impact properties, at both room temperature and a low temperature

Codes for the Quantum Erasure Channel

The quantum erasure channel (QEC) is considered. Codes for the QEC have to correct for erasures, i. e., arbitrary errors at known positions. We show that four qubits are necessary and sufficient to encode one qubit and correct one erasure, in contrast to five qubits for unknown positions. Moreover, a family of quantum codes for the QEC, the quantum BCH codes, that can be efficiently decoded is introduced.Comment: 6 pages, RevTeX, no figures, submitted to Physical Review A, code extended to encode 2 qubits, references adde

Error Prevention Scheme with Four Particles

It is shown that a simplified version of the error correction code recently suggested by Shor exhibits manifestation of the quantum Zeno effect. Thus, under certain conditions, protection of an unknown quantum state is achieved. Error prevention procedures based on four-particle and two-particle encoding are proposed and it is argued that they have feasible practical implementations.Comment: 4 pages, RevTeX, references updated and improved protocol adde

Holonomic quantum computation with neutral atoms

We propose an all-geometric implementation of quantum computation using neutral atoms in cavity QED. We show how to perform generic single- and two-qubit gates, the latter by encoding a two-atom state onto a single, many-level atom. We compare different strategies to overcome limitations due to cavity imperfections.Comment: 14 pages, 9 figure

Quantum Bit Regeneration

Decoherence and loss will limit the practicality of quantum cryptography and computing unless successful error correction techniques are developed. To this end, we have discovered a new scheme for perfectly detecting and rejecting the error caused by loss (amplitude damping to a reservoir at T=0), based on using a dual-rail representation of a quantum bit. This is possible because (1) balanced loss does not perform a ``which-path'' measurement in an interferometer, and (2) balanced quantum nondemolition measurement of the ``total'' photon number can be used to detect loss-induced quantum jumps without disturbing the quantum coherence essential to the quantum bit. Our results are immediately applicable to optical quantum computers using single photonics devices.Comment: 4 pages, postscript only, figures available at http://feynman.stanford.edu/qcom